- Real Sociedad VS Manchester United (Juventus Stadium)
- Wolfsberg VS Tottenham (Wörthersee Stadium)
- Olympiacos VS PSV (Karaiskakis Stadium)
- Slavia Praha VS Leicester City (Eden Arena)
- Young Boys VS Bayrn Leverkusen (Stade de Suisse)
- Crvena Zvezda VS AC Milan (Red Star Stadium)
- Dynamo Kyiv VS Club Brugge (NSC Olimpiskiy)
- Sporting Braga VS AS Roma (Estádio Municipal de Braga)
- Krasnodar VS Dinamo Zagreb (Krasnodar Stadium)
- Lille VS Ajax Amsterdam (Stade apierre-Mauroy)
Jumat, 19 Februari 2021, Pukul 03:00 (Leg 1)